Inhibitor or vehicle were added to the monolayers 24?h before measurement. the presence or absence of the ADAM10/17 inhibitors GI254023X and GW280264X. Expression of ADAM10, ADAM17 and VE-Cadherin in endothelial cells was quantified by immunoblotting and qRT. VE-Cadherin was additionally analyzed by immunofluorescence microscopy and ELISA. Results Ionizing radiation increased the permeability of endothelial monolayers … Continue reading Inhibitor or vehicle were added to the monolayers 24?h before measurement